Methylsulfonylmethane (MSM) C
A single RCT showed no protection of muscle after exercise; data are scarce
Citable fact
«Methylsulfonylmethane (MSM)» — evidence level C. Dosage: The studies used 1.5–6 g per day in courses of 12–24 weeks, including 3 g per day in a half-marathon study. No safe upper level has been established; doses up to 6 g per day were tolerated satisfactorily. Source: PMID 28736511, permanent link to the source in the list below.
How it works
A sulfur donor for the synthesis of glycosaminoglycans and collagen; a weak anti-inflammatory effect via NF-κB suppression is discussed. In humans the mechanism has not been confirmed.
Dosage and intake
The studies used 1.5–6 g per day in courses of 12–24 weeks, including 3 g per day in a half-marathon study. No safe upper level has been established; doses up to 6 g per day were tolerated satisfactorily.
In divided doses, 2–3 times a day with food, in courses.
Forms
Dimethyl sulfone powder and capsules have been studied; there are no optimized forms or proven differences.
What is confirmed
- In some small studies it reduced pain and stiffness in knee osteoarthritis
- Data on reduction of markers of inflammation and muscle damage after exercise are limited and contradictory
Adverse effects and limitations
- Nausea, diarrhea, headache, insomnia are possible
- There is little data on long-term safety and on sports outcomes
- Allergy to sulfonyl compounds — a contraindication
Interactions
- No significant interactions have been described; caution with anticoagulants
Who must not use it
- Under 18 years: No data; not recommended.
- Pregnancy and lactation: No safety data; not recommended.
- allergy to sulfonyl compounds
- pregnancy and lactation
- taking anticoagulants
Sources
- Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial · Withee ED, Tippens KM, Dehen R · Journal of the International Society of Sports Nutrition, 2017 · PMID 28736511
- Essential Features of Third-Party Certification Programs for Dietary Supplements: A Consensus Statement · Eichner AK, Coyles J, Fedoruk M · Current sports medicine reports, 2019 · PMID 31082891
See also
Open in the app
This page holds reference data with links to studies. In the app you can calculate calories and macros for your goal, build a personal supplement stack and review weekly training volume.