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Creatine monohydrate or Creatine HCl?
Both items are reviewed in the reference. Below their characteristics sit side by side as the studies describe them. This is a comparison of data, not advice on what to choose.
| Creatine monohydrate | Creatine HCl | |
|---|---|---|
| evidence level | A | C |
| Sources in the review | 4 | 2 |
| Category | Base | Overrated |
| Goals | Mass, Strength, Recomposition, Endurance | Mass, Strength, Endurance, Fat loss |
| Dosage | 3-5 g per day continuously; a loading phase of 20 g/day (4x5 g) for 5-7 days speeds up saturation but is not mandatory. The form is monohydrate; alternative forms have shown no advantages. | 3–5 g per day on an ongoing basis, or 1–2 g each in several HCl doses, as manufacturers suggest. For monohydrate, if needed, a loading protocol of 20 g per day divided into 4 doses is used for 5–7 days |
| When to take | The time of intake has practically no effect on the result: daily intake matters, including on rest days. It is convenient to take with carbohydrate or protein food. | Daily; the time of intake is not of fundamental importance; taking it with carbohydrates and protein may slightly improve creatine retention in muscle. With the loading protocol, monohydrate is taken 4 times a day |
The conclusion from the data. In the reference «Creatine monohydrate» Level A and 4 sources, while «Creatine HCl» — Level C and 2. A higher level means the effect is better supported by research, not that the item suits you better.
Verdicts
Creatine monohydrate
The most studied supplement: a consistent moderate improvement in strength and muscle gain
Creatine HCl
No proven advantages over monohydrate; overpayment
Sources for both items
- International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine · Kreider RB, Kalman DS, Antonio J · Journal of the International Society of Sports Nutrition, 2017 · PMID 28615996
- Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? · Antonio J, Candow DG, Forbes SC · Journal of the International Society of Sports Nutrition, 2021 · PMID 33557850
- Creatine Supplementation in Women's Health: A Lifespan Perspective · Smith-Ryan AE, Cabre HE, Eckerson JM · Nutrients, 2021 · PMID 33800439
- Performance-Enhancing Drugs in Healthy Athletes: An Umbrella Review of Systematic Reviews and Meta-analyses · Warrier AA, Azua EN, Kasson LB · Sports health, 2024 · PMID 37688400