← All comparisons
Citrulline malate or Arginine?
Both items are reviewed in the reference. Below their characteristics sit side by side as the studies describe them. This is a comparison of data, not advice on what to choose.
| Citrulline malate | Arginine | |
|---|---|---|
| evidence level | B | C |
| Sources in the review | 2 | 2 |
| Category | For the goal | Overrated |
| Goals | Mass, Strength, Endurance | Endurance, Mass, Strength |
| Dosage | 6-8 g 40-60 minutes before exercise; in studies more often 8 g. Forms: citrulline malate 1:1 or 2:1, less often pure L-citrulline. | 3–6 g per day in several doses at minimum; studies used doses up to 6–12 g. Even high oral doses give a smaller effect than 6–8 g of citrulline |
| When to take | 40-60 minutes before training. The effect on plasma accumulation is single-dose; a course is not required. | In divided doses during the day or 60–90 minutes before training. A single large dose is tolerated worse than a divided one |
The conclusion from the data. In the reference «Citrulline malate» Level B and 2 sources, while «Arginine» — Level C and 2. A higher level means the effect is better supported by research, not that the item suits you better.
Verdicts
Citrulline malate
A modest effect: an increase in the number of repetitions is possible, the data are heterogeneous
Arginine
Works poorly orally; the effect is weaker than that of citrulline
Sources for both items
- A critical review of citrulline malate supplementation and exercise performance · Gough LA, Sparks SA, McNaughton LR · European journal of applied physiology, 2021 · PMID 34417881
- The Top 5 Can't-Miss Sport Supplements · Antonio J, Pereira F, Curtis J · Nutrients, 2024 · PMID 39408214
- Effect of food sources of nitrate, polyphenols, L-arginine and L-citrulline on endurance exercise performance: a systematic review and meta-analysis of randomised controlled trials · d'Unienville NMA, Blake HT, Coates AM · Journal of the International Society of Sports Nutrition, 2021 · PMID 34965876