Green coffee (chlorogenic acid) B
Meta-analysis: about 1 kg over 8–12 weeks; the effect is small and inconsistent
Citable fact
«Green coffee (chlorogenic acid)» — evidence level B. Dosage: In a meta-analysis — 200–1000 mg of extract per day (usually 400 mg) for 4–12 weeks. The reduction in body weight relative to placebo is small, about 1 kg. Source: PMID 37710316, permanent link to the source in the list below.
How it works
The main component is chlorogenic acid, which slows glucose absorption and may affect glucose and fat metabolism. The beans are unroasted, so caffeine is present in variable amounts, which makes it difficult to separate the effects.
Dosage and intake
In a meta-analysis — 200–1000 mg of extract per day (usually 400 mg) for 4–12 weeks. The reduction in body weight relative to placebo is small, about 1 kg.
Usually 30 minutes before a meal 2–3 times a day; no advantage of a specific time has been shown.
Forms
Unroasted bean extract standardized for chlorogenic acid. Caffeine content varies and is often not stated.
What is confirmed
- 2023 meta-analysis of RCTs: a small statistically significant reduction in body weight and body mass index, about 1 kg
- Effects on waist circumference and body composition in the studies are inconsistent
- Part of the effect may be related to caffeine rather than chlorogenic acid
Adverse effects and limitations
- Because of caffeine, insomnia, anxiety, tremor and increased blood pressure are possible
- GI upset, headache and stomach irritation are possible
- Cases of hepatotoxicity have been described with high-dose green coffee extracts
- Caffeine content in products is not standardized, so the dose is unpredictable
Interactions
- Enhances the effect of stimulants and caffeine; affects the effect of antihypertensive drugs
- Metabolized via CYP1A2: caution with theophylline and clozapine
Who must not use it
- Under 18 years: Not recommended because of the caffeine content.
- Pregnancy and lactation: Not recommended: excess caffeine in pregnancy is undesirable, and there are no safety data.
- hypertension
- arrhythmias
- anxiety disorders
- insomnia
- liver disease
Sources
- Chlorogenic acid in green bean coffee on body weight: a systematic review and meta-analysis of randomized controlled trials · Kanchanasurakit S, Saokaew S, Phisalprapa P · Systematic reviews, 2023 · PMID 37710316
- Current Evidence to Propose Different Food Supplements for Weight Loss: A Comprehensive Review · Watanabe M, Risi R, Masi D · Nutrients, 2020 · PMID 32962190
See also
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