Forskolin (Coleus forskohlii) C
Small studies of questionable quality; there is no independent confirmation of the effect
Citable fact
«Forskolin (Coleus forskohlii)» — evidence level C. Dosage: In studies — 250–500 mg of extract with 10–20% forskolin (that is, 25–100 mg of forskolin) per day. Studies are few and often lack independent control. Source: PMID 32962190, permanent link to the source in the list below.
How it works
A diterpene from Coleus forskohlii that directly activates adenylate cyclase and raises intracellular cAMP levels. Theoretically this enhances lipolysis, but the systemic effect when taken orally is limited by low bioavailability.
Dosage and intake
In studies — 250–500 mg of extract with 10–20% forskolin (that is, 25–100 mg of forskolin) per day. Studies are few and often lack independent control.
Usually 2 doses a day before meals; there is no experimental justification for the timing.
Forms
Coleus forskohlii root extract standardized for forskolin; most often found as part of fat-burner mixes.
What is confirmed
- A 2020 review of weight-loss supplements classifies forskolin as an agent without convincing evidence
- Claims of increased testosterone and lean mass rest on a few small studies and have not been reproduced
- Positive results were obtained in studies involving the manufacturer and without adequate control
Adverse effects and limitations
- Lowered blood pressure, headache, flushing and rapid heartbeat are possible
- A theoretical risk in cardiovascular disease because of the effect on cAMP
- There are no data on long-term safety
Interactions
- May enhance the effect of antihypertensive drugs and anticoagulants
- Caution with drugs that raise cAMP and with phosphodiesterase inhibitors
Who must not use it
- Under 18 years: Not recommended.
- Pregnancy and lactation: Not recommended: there are no safety data.
- hypotension
- cardiovascular diseases
- use of antihypertensive and anticoagulant drugs
Sources
- Current Evidence to Propose Different Food Supplements for Weight Loss: A Comprehensive Review · Watanabe M, Risi R, Masi D · Nutrients, 2020 · PMID 32962190
- Effectiveness of herbal medicines for weight loss: A systematic review and meta-analysis of randomized controlled trials · Maunder A, Bessell E, Lauche R · Diabetes, obesity & metabolism, 2020 · PMID 31984610
See also
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