Oral ATP C
A meta-analysis of small studies; the quality of the data is low, the effect is unclear
Citable fact
«Oral ATP» — evidence level C. Dosage: 350-500 mg per day, usually 400 mg 30 minutes before exercise. Higher doses have not been studied systematically and more often give side effects. Source: PMID 38535745, permanent link to the source in the list below.
How it works
ATP is the universal energy molecule of the cell. When taken orally it does not reach the muscles unchanged, but is broken down to adenosine, which acts as a signaling molecule through purinergic receptors. The discussed effects are vasodilation, improved oxygen delivery, modulation of inflammation and, possibly, an effect on neuromuscular excitability. That is, the action is indirect and does not amount to "fuelling" the muscles with energy.
Dosage and intake
350-500 mg per day, usually 400 mg 30 minutes before exercise. Higher doses have not been studied systematically and more often give side effects
30 minutes before exercise. Cyclic use has been studied in some works, but there are few data for recommendations on duration
Forms
Sublingual tablets and oral ATP capsules. Ordinary ATP in powder penetrates mucous membranes poorly and degrades quickly
What is confirmed
- In some studies it improved anaerobic performance in trained people
- May affect blood flow through purinergic receptors
- It was studied as a means of reducing fatigue during repeated efforts
Adverse effects and limitations
- The evidence base consists of several small studies with low power, and the effect is not reproduced consistently between works
- Oral ATP does not reach the muscles as an energy source - the expectation of "fuelling muscles with ATP" does not match reality
- Bradycardia, lowered blood pressure, chest discomfort and skin flushing are possible
- A high price with unconvincing benefit
Interactions
- With antiarrhythmic drugs - risk of increased bradycardia
- With antihypertensive agents - summation of the blood pressure reduction
- With caffeine - antagonism at adenosine receptors
Who must not use it
- Under 18 years: There are no studies in children and adolescents; not recommended
- Pregnancy and lactation: Use during pregnancy and lactation has not been studied
- Bradycardia and cardiac conduction disorders - contraindicated
- Hypotension - caution
- Bronchial asthma - adenosine may provoke bronchospasm
- Taking antiarrhythmic drugs - only as prescribed by a physician
Sources
See also
Open in the app
This page holds reference data with links to studies. In the app you can calculate calories and macros for your goal, build a personal supplement stack and review weekly training volume.